Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC051
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-06 17:51
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 22 individuals with a value less than 0.59 were subsequently diagnosed with PD. That is, 52.38% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.59 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 10, 'TP': 31, 'FP': 20}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 14, 'TP': 22, 'FP': 16}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.464
timePerCircleCoV 0.343724
timePerCircleSlope -0.074999
meanError 1.2733
tremorFreq 5.27344
tremorRelPower 25.2285
tremorGyroAmpMean 0.0292482
tremorGyroAmpSlope 0.00134855
tremorGyroAmpCoV 0.432818
tremorCoordAmpMean 0.0510178
tremorCoordAmpSlope -5.81709e-05
tremorCoordAmpCoV 0.354659
tremorAccAmpMean 0.040025
tremorAccAmpSlope -0.000795196
tremorAccAmpCoV 0.443093
tremorPcRelVar 0.68064
tremorPcX -0.451436
tremorPcY 0.892304

Circle Segment 1

Duration 22.32 s, Accuracy Estimate 1.85 (lower is better)

Circle Segment 2

Duration 18.12 s, Accuracy Estimate 1.507 (lower is better)

Circle Segment 3

Duration 10.64 s, Accuracy Estimate 1.085 (lower is better)

Circle Segment 4

Duration 10.16 s, Accuracy Estimate 0.979 (lower is better)

Circle Segment 5

Duration 10.04 s, Accuracy Estimate 1.066 (lower is better)

Circle Segment 6

Duration 9.6 s, Accuracy Estimate 0.958 (lower is better)

Circle Segment 7

Duration 10.84 s, Accuracy Estimate 1.12 (lower is better)

Circle Segment 8

Duration 12.04 s, Accuracy Estimate 0.96 (lower is better)

Circle Segment 9

Duration 11.52 s, Accuracy Estimate 0.861 (lower is better)

Circle Segment 10

Duration 9.36 s, Accuracy Estimate 2.347 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 45.06
timePerSpiralCoV 0.0419679
timePerSpiralSlope 0.0134678
meanError 1.45208
tremorFreq 7.03125
tremorRelPower 26.1434
tremorGyroAmpMean 0.0226448
tremorGyroAmpSlope -0.00148658
tremorGyroAmpCoV 0.460316
tremorCoordAmpMean 0.0350669
tremorCoordAmpSlope -0.00101067
tremorCoordAmpCoV 0.406954
tremorAccAmpMean 0.0272598
tremorAccAmpSlope -0.00117592
tremorAccAmpCoV 0.504427
tremorPcRelVar 0.721012
tremorPcX 0.538178
tremorPcY 0.842831

Spiral Segment 1

Duration 41.92 s, Accuracy Estimate 1.624 (lower is better)

Spiral Segment 2

Duration 45.12 s, Accuracy Estimate 1.273 (lower is better)

Spiral Segment 3

Duration 46.56 s, Accuracy Estimate 1.505 (lower is better)

Spiral Segment 4

Duration 45.8 s, Accuracy Estimate 1.516 (lower is better)

Spiral Segment 5

Duration 43.92 s, Accuracy Estimate 1.473 (lower is better)

Spiral Segment 6

Duration 47.04 s, Accuracy Estimate 1.321 (lower is better)

Elel

eDurationMean 0.502361
eDurationStd 0.0939946
eDurationStdnorm 0.187106
eDurationMedian 0.5025
eDurationQuartdelta 0.155
eDurationQuartdeltanorm 0.308458
eDurationKurt 2.23048
eDurationTrenddiff 0.105
eDurationTrendratio 1.22703
eWidthMean 3.38
eWidthStd 1.0283
eWidthStdnorm 0.304231
eWidthMedian 3.2175
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.472727
eWidthKurt 2.49082
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 5.226
eHeightStd 1.07123
eHeightStdnorm 0.20498
eHeightMedian 5.148
eHeightQuartdelta 1.755
eHeightQuartdeltanorm 0.340909
eHeightKurt 2.0225
eHeightTrenddiff -0.819
eHeightTrendratio 0.854167
eAspectMean 0.638843
eAspectStd 0.0996605
eAspectStdnorm 0.156002
eAspectMedian 0.656696
eAspectQuartdelta 0.136179
eAspectQuartdeltanorm 0.20737
eAspectKurt 3.42564
eAspectTrenddiff 0.0700155
eAspectTrendratio 1.11463
eSlantMean -0.0317039
eSlantStd 0.206719
eSlantStdnorm -6.5203
eSlantMedian 0
eSlantQuartdelta 0.230361
eSlantQuartdeltanorm -7.26604
eSlantKurt 4.70136
eSlantTrenddiff 0.0111111
eRtopMean 0.690032
eRtopStd 0.12537
eRtopStdnorm 0.181687
eRtopMedian 0.716236
eRtopQuartdelta 0.196145
eRtopQuartdeltanorm 0.273855
eRtopKurt 2.32363
eRtopTrenddiff -0.0274675
eRbotMean 0.767329
eRbotStd 0.273807
eRbotStdnorm 0.356831
eRbotMedian 0.718071
eRbotQuartdelta 0.298714
eRbotQuartdeltanorm 0.415995
eRbotKurt 4.07146
eRbotTrenddiff -0.020154
eRrightMean 0.866181
eRrightStd 0.0546498
eRrightStdnorm 0.0630928
eRrightMedian 0.869694
eRrightQuartdelta 0.0702671
eRrightQuartdeltanorm 0.0807952
eRrightKurt 2.99047
eRrightTrenddiff 0.00112803
eRleftMean 0.405245
eRleftStd 0.0900793
eRleftStdnorm 0.222283
eRleftMedian 0.395801
eRleftQuartdelta 0.0894167
eRleftQuartdeltanorm 0.225913
eRleftKurt 5.04874
eRleftTrenddiff 0.0386436
lDurationMean 0.538824
lDurationStd 0.154621
lDurationStdnorm 0.28696
lDurationMedian 0.5025
lDurationQuartdelta 0.21
lDurationQuartdeltanorm 0.41791
lDurationKurt 3.76232
lDurationTrenddiff 0.09
lDurationTrendratio 1.19355
lWidthMean 4.02274
lWidthStd 1.1586
lWidthStdnorm 0.288014
lWidthMedian 4.095
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.514286
lWidthKurt 1.98705
lWidthTrenddiff -1.521
lWidthTrendratio 0.682927
lHeightMean 10.5094
lHeightStd 2.17832
lHeightStdnorm 0.207274
lHeightMedian 10.1205
lHeightQuartdelta 2.925
lHeightQuartdeltanorm 0.289017
lHeightKurt 3.71042
lHeightTrenddiff -1.989
lHeightTrendratio 0.828283
lAspectMean 0.379811
lAspectStd 0.0624408
lAspectStdnorm 0.1644
lAspectMedian 0.384649
lAspectQuartdelta 0.0742009
lAspectQuartdeltanorm 0.192905
lAspectKurt 2.18589
lAspectTrenddiff -0.00263158
lAspectTrendratio 0.993182
lSlantMean 0.0594654
lSlantStd 0.105791
lSlantStdnorm 1.77904
lSlantMedian 0.0493941
lSlantQuartdelta 0.148049
lSlantQuartdeltanorm 2.99731
lSlantKurt 2.68521
lSlantTrenddiff -0.0743481
lRtopMean 0.825193
lRtopStd 0.0718234
lRtopStdnorm 0.0870383
lRtopMedian 0.827678
lRtopQuartdelta 0.0997732
lRtopQuartdeltanorm 0.120546
lRtopKurt 2.94658
lRtopTrenddiff -0.00318134
lRbotMean 0.693043
lRbotStd 0.256209
lRbotStdnorm 0.369687
lRbotMedian 0.658915
lRbotQuartdelta 0.318182
lRbotQuartdeltanorm 0.482888
lRbotKurt 3.24876
lRbotTrenddiff 0.0759582
lRrightMean 0.913036
lRrightStd 0.0506573
lRrightStdnorm 0.0554822
lRrightMedian 0.935484
lRrightQuartdelta 0.0882867
lRrightQuartdeltanorm 0.0943755
lRrightKurt 2.6181
lRrightTrenddiff 0.0443948
lRleftMean 0.2389
lRleftStd 0.0752639
lRleftStdnorm 0.315043
lRleftMedian 0.254033
lRleftQuartdelta 0.095735
lRleftQuartdeltanorm 0.37686
lRleftKurt 2.72213
lRleftTrenddiff 0.00454339

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.961778
sumTouchScores 27.8916
meanMovementTime 0.710357
numTouches 29
undershootPercentage 0
overshootPercentage 6.89655

FITTS Long Modified

meanTouchScore 0.933996
sumTouchScores 20.5479
meanMovementTime 0.774048
numTouches 22
undershootPercentage 4.54545
overshootPercentage 9.09091

ZigZag

numZigzags 5
timePerZigzagMean 54.936
timePerZigzagCoV 0.0562225
timePerZigzagSlope -0.0218436
meanError 1.87009
tremorFreq 6.73828
tremorRelPower 25.1726
tremorGyroAmpMean 0.0208849
tremorGyroAmpSlope 0.000462269
tremorGyroAmpCoV 0.553548
tremorCoordAmpMean 0.0445196
tremorCoordAmpSlope -0.000499828
tremorCoordAmpCoV 0.728757
tremorAccAmpMean 0.024956
tremorAccAmpSlope 8.18918e-05
tremorAccAmpCoV 0.42954
tremorPcRelVar 0.838858
tremorPcX -0.0140459
tremorPcY 0.999901

ZigZag Segment 1

Duration 54.76 s, Accuracy Estimate 1.918 (lower is better)

ZigZag Segment 2

Duration 60.16 s, Accuracy Estimate 1.775 (lower is better)

ZigZag Segment 3

Duration 54.12 s, Accuracy Estimate 1.969 (lower is better)

ZigZag Segment 4

Duration 53.6 s, Accuracy Estimate 1.764 (lower is better)

ZigZag Segment 5

Duration 52.04 s, Accuracy Estimate 1.924 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.816
timePerZigzagCoV 0.223109
timePerZigzagSlope -0.122943
zigzagHeightMean 57.4986
zigzagHeightCoV 0.0275224
zigzagHeightSlope 0.0136905
meanError 0.0293605
tremorFreq 6.34766
tremorRelPower 32.5422
tremorGyroAmpMean 0.0203663
tremorGyroAmpSlope -0.000520836
tremorGyroAmpCoV 0.399043
tremorCoordAmpMean 0.0941791
tremorCoordAmpSlope 0.00816072
tremorCoordAmpCoV 1.45743
tremorAccAmpMean 0.052754
tremorAccAmpSlope 0.000102879
tremorAccAmpCoV 0.130385
tremorPcRelVar 0.898192
tremorPcX 0.238171
tremorPcY -0.971223

ZigZag Offset Segment 1

Duration 32.84 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 2

Duration 23.96 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 3

Duration 21.2 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 4

Duration 21.8 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 5

Duration 19.28 s, Accuracy Estimate 0.044 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.85}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.59}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5291873097049249}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8080902379457067}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}